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[Met(O)21] Corticotropin ReleasingFactor, ovine is a corticotropin releasingfactor isolated from ovine hypothalamic extracts. Corticotropin releasingfactor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH) .
a-Helical Corticotropin ReleasingFactor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasingfactor/hormone. Corticotropin releasingfactor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin ReleasingFactor (12-41) would suppress the stimulatory effect .
[DPro5] Corticotropin ReleasingFactor, human, rat is a selective R2 agonist of corticotropin releasingfactor/hormone. Corticotropin releasingfactor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin ReleasingFactor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .
[DPro5] Corticotropin ReleasingFactor, human, rat TFA is a selective corticotropin releasingfactor/hormone R2 (CRH-R2)agonist. [DPro5] Corticotropin ReleasingFactor, human, rat TFA fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .
Antalarmin is a selective nonpeptide corticotropin-releasingfactor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM. Antalarmin can pass through the blood–brain barrier .
[Asu1,6-Arg8]Vasopressin is an vasopressin agonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasingfactor (CRF) in rat anterior pituitary cells in culture .
Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasingfactor (CRF) concentrations in rat brain .
Astressin 2B is a potent and selective corticotropin-releasingfactor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .
Astressin 2B TFA is a potent and selective corticotropin-releasingfactor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .
Urocortin III (human) is a corticotropin-releasingfactor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion .
Verucerfont is a corticotropin-releasingfactor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.
Cortagine is a specific corticotropin-releasingfactor receptor subtype 1 (CRF1) agonist with an EC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive agent in the mouse model .
Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasingfactor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .
Urocortin II, human (TFA) is a selective endogenous peptide agonist of type-2 corticotropin-releasingfactor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .
BMS-665053 is a corticotropin-releasingfactor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM) .
(Tyr0)-Urocortin, rat is a high-affinity agonist of corticotropin-releasingfactor receptor type 1 (CRF-R1) and type 2 (CRF-R2). (Tyr0)-Urocortin, rat shows inhibitory binding constants (Ki) of 1-2 nM .
Urocortin III, mouse is a corticotropin-releasingfactor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2 . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics .
Urocortin III, mouse TFA is a corticotropin-releasingfactor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2 . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics .
NBI 35965 hydrochloride is a selective, orally active and brain-penetrant corticotropin-releasingfactor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 hydrochloride does not inhibit CRF2. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride shows anxiolytic effects .
NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasingfactor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects .
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasingfactor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca 2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .
Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasingfactor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .
SN003 is a reversible antagonist of corticotropin releasingfactor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat .
[Tyr0] Corticotropin ReleasingFactor, ovine is a corticotropin releasingfactor/hormone isolated from ovine. Corticotropin releasingfactor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin .
[Met(O)21] Corticotropin ReleasingFactor, ovine is a corticotropin releasingfactor isolated from ovine hypothalamic extracts. Corticotropin releasingfactor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH) .
a-Helical Corticotropin ReleasingFactor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasingfactor/hormone. Corticotropin releasingfactor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin ReleasingFactor (12-41) would suppress the stimulatory effect .
[DPro5] Corticotropin ReleasingFactor, human, rat is a selective R2 agonist of corticotropin releasingfactor/hormone. Corticotropin releasingfactor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin ReleasingFactor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .
[DPro5] Corticotropin ReleasingFactor, human, rat TFA is a selective corticotropin releasingfactor/hormone R2 (CRH-R2)agonist. [DPro5] Corticotropin ReleasingFactor, human, rat TFA fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .
[Asu1,6-Arg8]Vasopressin is an vasopressin agonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasingfactor (CRF) in rat anterior pituitary cells in culture .
Astressin 2B is a potent and selective corticotropin-releasingfactor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .
Astressin 2B TFA is a potent and selective corticotropin-releasingfactor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .
Urocortin III (human) is a corticotropin-releasingfactor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion .
Cortagine is a specific corticotropin-releasingfactor receptor subtype 1 (CRF1) agonist with an EC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive agent in the mouse model .
Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasingfactor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .
Urocortin II, human (TFA) is a selective endogenous peptide agonist of type-2 corticotropin-releasingfactor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior .
(Tyr0)-Urocortin, rat is a high-affinity agonist of corticotropin-releasingfactor receptor type 1 (CRF-R1) and type 2 (CRF-R2). (Tyr0)-Urocortin, rat shows inhibitory binding constants (Ki) of 1-2 nM .
Urocortin III, mouse is a corticotropin-releasingfactor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2 . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics .
Urocortin III, mouse TFA is a corticotropin-releasingfactor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2 . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics .
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasingfactor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca 2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .
CRHBP Protein critically regulates by binding to and inactivating corticotropin-releasing factor (CRF), suggesting a role in preventing excessive pituitary-adrenal stimulation, especially during pregnancy. This interaction contributes to balancing neuroendocrine signaling pathways, ensuring appropriate physiological responses and safeguarding against pituitary-adrenal axis overstimulation, particularly in the context of pregnancy. CRHBP Protein, Human (HEK293, His) is the recombinant human-derived CRHBP protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CRHBP Protein, Human (HEK293, His) is 298 a.a., with molecular weight of ~40.0 kDa.
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![[Met(O)21] <em>Corticotropin Releasing</em> <em>Factor</em>, ovine](http://file.medchemexpress.com/product_pic/hy-p3685.gif)
![[DPro5] <em>Corticotropin Releasing</em> <em>Factor</em>, human, rat](http://file.medchemexpress.com/product_pic/hy-p3684.gif)
![[DPro5] <em>Corticotropin Releasing</em> <em>Factor</em>, human, rat TFA](http://file.medchemexpress.com/product_pic/hy-p3684a.gif)
![[Asu1,6-Arg8]Vasopressin](http://file.medchemexpress.com/product_pic/hy-p4012.gif)
